Serum levels of IL-33 and sST2 were significantly higher in patients with SSc compared to HCs [98 pg/mL (70–152) vs. 55 pg/mL (28–92), p < 0.01, and 9115 pg/mL (6854–12,696) vs. 7031 (4862–8269), p < 0.05, respectively]. Here, IL33 is linked to systemic sclerosis.