APP and nervous system disorder: It has been reported that the splicing of the APP, APOE, SNCA, MAPT, DAO, SHANK3, and CACNA1C genes, which are recorded in the PsyGeNET database, were abnormal in patients with neurological diseases such as Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis [27,30,51,52,53].