However, in chronic diseases such as osteoarthritis, non-alcoholic steatohepatitis, and Brucella abortus infection, GPR84 plays a role in modulating inflammation by reducing the expression of pro-inflammatory factors (such as TNF-α), thereby alleviating disease progression or promoting infection [16,52,53]. The gene discussed is TNF; the disease is metabolic dysfunction-associated steatohepatitis.