In most patients with chronic periodontitis, it can significantly reduce the pro-inflammatory cytokine response (such as TNF-α, IL-1β, and IL-17) and improve the clinical indicators of periodontitis (including sulcus bleeding index SBI, periodontal probing depth PPD, clinical attachment level CAL), which may help to alleviate the activity of the disease [100,101,102,103,104,105]. Here, TNF is linked to periodontitis.