Genetic analysis showed that the coronary artery disease-associated risk variant rs2832227 was associated with BACH1 gene expression in patients’ carotid plaques, and endothelial Bach1 deficiency reduced turbulent blood flow or Western diet-induced atherosclerotic lesions in atherosclerotic mice, macrophage content in plaques, endothelial cell adhesion molecule (ICAM1 and VCAM1) expression, and decreased blood TNF-α due to IL-1β sub [87]. Here, BACH1 is linked to coronary artery disorder.