This further analysis revealed there were four newborns having microcephaly (three newborns at 1 day of life and one at 27 days of life) that had IgM antibodies against OROV in serum samples (one newborn at 1 day of life and another at 27 days of life) and cerebrospinal fluid (two newborns at 1 day of life and a newborn at 27 days of life, in which IgM was also detected in cerebrospinal fluid) [46,54]. This evidence concerns the gene CD40LG and microcephaly.