Antoniou et al. reported an absolute risk of breast cancer for women carrying P/LP variants in PALB2 by the age of 70 of 33% (95% CI 25–44) for those with no affected relatives and 58% (95% CI 50–66) for those with two first-degree relatives with breast cancer diagnosed by the age of 50 [32]. This evidence concerns the gene PALB2 and breast cancer.