For instance, heterozygosis in PALB2, BRIP1, and ATM increases the lifetime risk of breast cancer, while homozygosis causes multisystemic genetic syndromes, such as Fanconi’s anemia (PALB2 and BRIP1) and ataxia-telangiectasia (ATM) [66,67,68]. The gene discussed is BRIP1; the disease is Fanconi anemia.