Kuchenbaecker et al. showed that the cumulative breast cancer risk by the age of 80 was 72% for BRCA1 and 69% for BRCA2 P/LP variant carriers; breast cancer incidence increased rapidly until the ages of 35 to 40 for BRCA1 and until the ages of 40 to 50 for BRCA2 carriers, and then the risk tends to stabilize until age 80 [23]. The gene discussed is BRCA1; the disease is breast cancer.