Kuchenbaecker et al. reported an increased risk of breast cancer for P/LP variants located outside versus within the regions bounded by positions c.2282-c.4071 in BRCA1 and c.2831-c.6401 in BRCA2 (HR 1.93; 95% CI 1.36–2.74; p < 0.001) [23]. This evidence concerns the gene BRCA2 and breast carcinoma.