TSPYL2 and squamous cell carcinoma: Since lung adenocarcinoma and squamous cell carcinoma, subtypes of NSCLC, originate from different cell types and exhibit different dependencies on the EGFR signaling pathway, with lung adenocarcinoma relying more strongly [75,76,77], these results suggest that TSPX-regulated genes, particularly those of the EGFR signaling pathway, may have lesser or different roles in lung squamous cell carcinoma pathogenesis under clinical conditions compared to that of lung adenocarcinoma.