Since lung adenocarcinoma and squamous cell carcinoma, subtypes of NSCLC, originate from different cell types and exhibit different dependencies on the EGFR signaling pathway, with lung adenocarcinoma relying more strongly [75,76,77], these results suggest that TSPX-regulated genes, particularly those of the EGFR signaling pathway, may have lesser or different roles in lung squamous cell carcinoma pathogenesis under clinical conditions compared to that of lung adenocarcinoma. This evidence concerns the gene TSPYL2 and lung adenocarcinoma.