Taken together, our results suggest that TSPX may suppress the development and/or progression of lung adenocarcinoma by downregulating AREG, BIRC3, DKK1, EREG, FOSL1, MYC, and PLAU, which could exacerbate lung adenocarcinoma, and upregulating the tumor suppressor CACNA2D2. The gene discussed is CACNA2D2; the disease is lung adenocarcinoma.