TSPYL2 and lung adenocarcinoma: Our results, however, have provided the initial clues in establishing the potential involvement of TSPX in the EGFR signaling and oncogenesis in lung adenocarcinoma, and a rationale for more detailed analyses with advanced strategies, such as in vivo CRISPR gene activation/inactivation [78,79], of this X-linked tumor suppressor gene in both preclinical and clinical models [80,81].