Second, it has been shown that increased LPL lipolytic activity is associated with reduced coronary heart disease and diabetes risk in humans [41,42], with increased insulin sensitization being observed in patients with mutations inactivating angiopoietin-like protein 3 (ANGPTL3), an inhibitor of LPL, and in ANGPTL3 knockout mice [43]. The gene discussed is ANGPTL3; the disease is diabetes mellitus.