LPL and pancreatitis: The frameshift variant impacting one of the Ca2+ coordinating residues, LPL:c.596delC:p.Ser199Phefs*8, is particularly interesting, as it was discovered in a heterozygous patient with no other TG-elevating variants suffering from recurrent HTG-linked pancreatitis episodes, and it was found that this variant was uniquely associated with an anti-LPL antibody that partially inhibited WT LPL activity in vitro and immunosuppressive therapy via azathioprine treatment significantly reduced plasma TG levels in this patient [101].