APP and early-onset autosomal dominant Alzheimer disease: In more precise terms, below (Section 35 and Section 36), we discuss the possibility that under the neuronal ISR conditions, γ-secretase is suppressed (or rather the production of its components is suppressed) and what drives Alzheimer’s disease is not iAβ but rather C100/C99 generated independently of AβPP (a process enabled by the neuronal ISR, as discussed above).