APP and early-onset autosomal dominant Alzheimer disease: Therefore, were this the case, Alzheimer’s disease is not driven (or not only driven) by iAβ produced independently of AβPP, as we proposed previously (e.g., Figure 2 above, see also [1,2,3,4,5,6,7,8,9]), but mainly, possibly exclusively, by C100/C99 generated in the AβPP-independent pathway.