The most common genetic alteration in AdCC is the fusion of the MYB gene to the transcription factor NFIB by a translocation t(6; 9) (q22–23; p23–24) that leads to sustained Myb protein stability [84], which regulates c-KIT on a transcriptional level [85]. This evidence concerns the gene NFIB and adrenocortical carcinoma, hereditary.