POU5F1 and adrenocortical carcinoma, hereditary: The expression of OCT4/POU5F1 and NANOG was correlated with increased risk for adverse histopathological prognostic factors, i.e., desmoplasia and perineural invasion, in MEC [23], while BMI1 expression was an adverse prognostic factor in AdCC, associated with shorter overall and disease-free survival [24].