In vivo Chchd6 knockdown experiments in mice showed improvement of steatosis and insulin resistance as also reduced mitochondrial respiration leading to a shift toward glycolytic metabolism, thus of NAFLD, suggesting the positive correlation of the gene with MASLD progression and highlighting mitochondria dysfunction as a key mechanistic driver of the disease [60]. The gene discussed is CHCHD6; the disease is metabolic dysfunction-associated steatotic liver disease.