Considering that AMPK negatively regulates mTOR signaling [30], it is not surprising that the hepatocyte-specific deletion of Ufl1 or Ddrgk1 in mice results in liver injury and increases susceptibility to HFD-induced fatty liver and diethylnitrosamine (DEN)-induced hepatocellular carcinoma by the activation of mTOR signaling [31]. The gene discussed is UFL1; the disease is fatty liver disease.