Interestingly, in a case of APL with a cryptic PML::RARA translocation, identified by RT-PCR, Koshy et al. detected a 49-kilobase duplication of 15q24.1 by SNP microarray, which likely inserted into chromosome 19 or 20; they hypothesize that the RARA insert in this case was too small to detect using FISH or microarray [39]. This evidence concerns the gene PML and acute promyelocytic leukemia.