In an institutional analysis over an 18.5-year timeframe, Gagnon et al. [9] found the majority of APL cases (87% [723/831]) to possess balanced PML::RARA translocations by chromosomal banding analysis and PML::RARA dual-color, dual-fusion FISH (Abbott).Of the remaining 13% of patients, only 0.7% (6/831) were found to harbor a cryptic PML::RARA gene fusion, confirmed by retrospective metaphase FISH in two cases [9]. This evidence concerns the gene PML and acute promyelocytic leukemia.