Similarly, administration of the Nrf2 activator CDDO methyl ester attenuates neurodegeneration primarily through the activation of the Nrf2 pathway, which stimulates the antioxidant signaling pathway and enhances autophagy in rotenone-induced Drosophila PD and 6-OHDA-induced rat PD models [37]. Here, NFE2L2 is linked to Parkinson disease.