The first mutation set encompasses the eight UM driver genes according to the TCGA study, divided into “uveal melanoma initiating mutations” (CYSLTR2, GNA11, GNAQ and PLCB4) and “second hit mutations with prognostic impact” (BAP1, EIF1AX, SF3B1 and SRSF2). The gene discussed is PLCB4; the disease is uveal melanoma.