An interesting mechanism of its oncogenic effect is based on the interaction between ARID3A and CEP131, that together transcriptionally activate KDM3A expression, which in turn demethylates H3K9me2 (H3 lysine 9 dimethylation) in the promoter regions of embryonic stem cell-like genes signature, leading to their up-regulation and thus facilitating liver cancer malignancy [46]. This evidence concerns the gene CEP131 and liver cancer.