Also, high contents of protein carbonyls in AD-affected individuals have been reported in different brain regions, such as the superior middle temporal gyrus, and O. majorana L. and sulfasalazine had protective effects against oxidative stress in ulcerative colitis induced by acetic acid in rats, manifested by decreases in MDA levels and increases in the activities of some antioxidant enzymes (SOD, CAT, and GSH). Here, SOD1 is linked to Alzheimer disease.