AR and Alzheimer disease: It will indeed be important to make such studies as there are many AR drugs that can easily be repurposed for AD, other dementias or neurodegenerative diseases [87,88,89,90], while repurposing for other antihypertensive drugs is also possible [91,92] A number of properties makes this class of drugs an attractive novel therapy for AD: their proven safety and their multi target drug ligand property, which is thought to be a very promising method for targeting complex neurodegenerative diseases [93].