Later, only five biomarkers [IL-8, CCL3, HSPA1B, granzyme B (GZMB), and matrix metalloproteinase 8 (MMP-8)] together with the age of the patient were considered, resulting in a model named PERSEVERE that was repeatedly tested and considered effective for the identification of a certain number of children with septic shock at high risk of mortality within the first 24 h of sepsis diagnosis [92]. The gene discussed is GZMB; the disease is Sepsis.