For instance, the loss of some components, such as Tregs and PD-1-mediated signaling, leads to lethal AIH, while the increased expression of PD-L1 and B7-DC on Kupffer cells and LSECs can lead to the binding of T cells through PD-1, thus suppressing autoreactive lymphocytes, which regulate the progression of AIH [166,167]. The gene discussed is CD274; the disease is autoimmune hepatitis.