CDK4 and acute myeloblastic leukemia with maturation: Key implicated pathways in the pathogenesis of AM include mitogen-activated protein kinase (MAPK/ERK) and phosphatidylinositol 3-kinase (PI3K/AKT) pathways affecting cell proliferation and survival, the TERT pathway affecting telomere maintenance, the CDK4/CDKN2A pathway affecting cell cycle regulation, and the MDM2/TP53 pathway affecting apoptosis and senescence [21].