Moreover, our studies utilized a range of leukemic cells, such as Bcr-Abl(+) cells, FLT3-ITD(+) MV4;11 cells, STAT5-A over-expressing RS4:11 cells, and primary mononuclear cells obtained from leukemia patients (bone marrow isolates), so that the RNAi platform is adoptable to a range of well-accepted leukemia cell models. Here, STAT5A is linked to leukemia.