Although many NRF2 activators have low bioavailability and induce off-target effects, a literature review by Niu et al. highlighted the efficacy of various NRF2 inducers, such as SFN, ellagic acid, and caffeic acid, among others, in improving proteostasis and motor function in PD models through the regulation of NRF2 activity [157]. This evidence concerns the gene NFE2L2 and Parkinson disease.