For example, using an animal model of PD, it has recently been demonstrated that dimethyl fumarate exerts neuroprotective effects by enhancing mitophagy through the NRF2/PINK1 axis, together with BCL2 interacting protein 3 (BNIP3), another key protein involved in the regulation of mitophagy [152]. The gene discussed is BNIP3; the disease is Parkinson disease.