POU5F1 and chronic myelogenous leukemia, BCR-ABL1 positive: Additionally, the potential roles of pluripotency-associated transcription factors such as POU5F1, SOX2, and NANOG in controlling TSPAN32 suggest its involvement in broader developmental and reprogramming contexts, including possible implications for onco-hematological disorders, such as chronic myeloid leukemia [17].