To explore the properties of morin in the upstream regulatory pathways involved in NLRP3 inflammasome activation and NSCLC metastasis in LPS+ATP-stimulated A549 and H1299 cells, the phosphorylation of key signaling molecules in the MAPK signaling pathway (ERK, JNK, and p38) was investigated by Western blotting. Here, MAPK8 is linked to non-small cell lung carcinoma.