To explore the properties of morin in the upstream regulatory pathways involved in NLRP3 inflammasome activation and NSCLC metastasis in LPS+ATP-stimulated A549 and H1299 cells, the phosphorylation of key signaling molecules in the MAPK signaling pathway (ERK, JNK, and p38) was investigated by Western blotting. The gene discussed is NLRP3; the disease is non-small cell lung carcinoma.