NLRP3 and breast carcinoma: Numerous studies have demonstrated the activation of the NLRP3 inflammasome by LPS+ATP in diverse cell types, including THP-1 macrophages [35], LX-2 hepatic stellate cells [36], MCF-12A and MDA-MB-231 breast cancer cells [37], and A549 non-small-cell lung cancer cells [16].