ARG1 and neoplasm: The expression of anti-inflammatory markers (i.e., Arg1, Fizz1 and Vegf) in tumor-associated macrophages can also be facilitated through the activation of mammalian target of rapamycin complex (MTORC) by intracellular lactate and the subsequent stabilization of HIF2α [133], or through the activation of ERK/STAT3 signaling [134].