Third, we did not investigate the cell origin of the EV: In particular, while, in U-VTE, circulating cancer-derived EV should be visually absent (with the possible exception of occult cancers not detectable at the time of VTE diagnosis), in C-VTE and C-w/o VTE, they are present by definition, but we do not know in which proportion they contribute to EV-TF activity. This evidence concerns the gene TF and cancer.