For example, this approach has been successfully applied in the classification of breast cancer, a heterogeneous disease with distinct molecular subtypes such as Luminal A (LUMA), Luminal B (LUMB), HER2-Enriched, and basal-like (similar to the triple-negative breast cancer, TNBC), each with different biological characteristics and clinical implications. This evidence concerns the gene ERBB2 and breast carcinoma.