In a study by Guan S, it was discovered that in a model of AKI induced by 3-monochloro-1,2-propanediol (3-MCPD), 3-MCPD inhibits the SIRT3/SOD2 pathway by altering the rhythmic expression of the Bmal1 gene, leading to mitochondrial damage in the kidney [79]. This evidence concerns the gene BMAL1 and acute kidney injury.