Nuclear SIRT1 protein expression was shown to be an independent predictive variable in multivariate logistic regression analyses in luminal A BC (p = 0.029, odds ratio [OR] of 0.313 confidence interval (CI) 0.890 (upper)–0.110 (lower)) but not in TNBC (p = 0.053, odds ratio [OR] of 3.130 CI 9.965 (upper)–0.983 (lower)). This evidence concerns the gene SIRT1 and breast cancer.