Similarly to the nuclear expression of SIRT1 in TN, cytoplasmic SIRT1 expression was associated with lymph node metastasis (p = 0.045), without being an independent predictive variable (p = 0.051, odds ratio [OR] of 3.420 CI 11.780 (upper)–0.993 (lower)) (Figure 5B). Here, SIRT1 is linked to metastatic malignant neoplasm in the lymph nodes.