More severe forms of psoriasis are associated with a high degree of inflammation, that are confirmed by psoriatic skin lesions and numerous inflammatory mediators such as TNFα, IL-1, IL- 6, IL-8, IL-17, IL-22, IL-23, INF-ɣ, homocysteine and hsCRP, which highly correspond with disease activity [4]. The gene discussed is IL1B; the disease is psoriasis.