MMP9 and colorectal carcinoma: An interesting study revealed that volatile anesthetics (sevoflurane and desflurane) reduce the release of MMP-9 from neutrophils and disrupt pathways downstream of CXCR2, but upstream of protein kinase C. Through downregulating MMP-9, these anesthetics decrease Matrigel degradation and subsequently hinder the invasion of CRC cells in vitro [107].