In a recent study that investigated early ER stress-induced adaptive mechanisms, 2-week-old iPSC-derived MNs from C9orf72-ALS/FTD patients had elevated GRP75 transcripts, accompanied by elevated VDAC1 transcripts and increased IP3R-VDAC1 interaction [137]. This evidence concerns the gene ITPR3 and amyotrophic lateral sclerosis.