Lastly, in human colon adenocarcinoma, naringenin can reduce the expression of several miRNAs, including miR-17-3p and miR-25-5p, involved in anti-inflammatory and antioxidant mechanisms, resulting in the upregulation of both glutathione peroxidase (GPX) 2 and manganese superoxide dismutase (SOD) [107]. This evidence concerns the gene SOD1 and colon adenocarcinoma.