SIRT1 and neoplasm: Moreover, quercetin regulates different miRNAs, like miR-145 and miR-146a, and regulatory axes including miR-22/WNT1/β-catenin, miR-197/IGFBP5, TP53/miR-15/miR-16, miR-16/HOXA10 and p53/miR-34a/SIRT1 in several tumor cell lines [7].