The model indicated that participants who were overweight/obese with PCOS were more likely to have higher levels of ANGPT1 (OR 3.85, 95% CI: 1.05–13.35, p < 0.001), programmed cell death 1 ligand 2 (PD-L2) (OR 2.22, 95% CI: 0.78–8.07, p < 0.004), and IL1-Ra (OR 0.98, 95% CI 0.31–8.35, p = 0.004). The gene discussed is ANGPT1; the disease is polycystic ovary syndrome.