In this exploratory investigation, 11 CVRPs were dysregulated in the entire PCOS group where IR and BMI were unmatched: leptin, IL-1Ra, PIGR, IL-18Ra, MIP-1a, and ANGPT1 were upregulated whereas sRAGE, BMP6, GDF2, Mn-SOD, and SLAF 5 were downregulated. The gene discussed is GDF2; the disease is polycystic ovary syndrome.