When both BMI (overweight/obese, BMI ≥ 26 kg/m2) and IR (HOMA-IR < 1.9) were accounted for, only two proteins, tissue factor (TF) and renin, were dysregulated (upregulated), indicating that both TF and renin were independent of both obesity and insulin resistance, suggesting that these may be CVRPs inherent to PCOS. The gene discussed is F3; the disease is obesity due to melanocortin 4 receptor deficiency.