In conclusion, a combination of upregulated obesity-related CVRPs (ANGPT1, IL, 1Ra, XCL1) and downregulated cardioprotective proteins (sRAGE, BMP6, Mn-SOD, GDF2) in PCOS may contribute to the increased risk of CVDs in overweight women with PCOS. This evidence concerns the gene GDF2 and obesity due to melanocortin 4 receptor deficiency.