ESR1 and urinary bladder cancer: The overexpression and adverse function of RACGAP1 in bladder cancer has undergone confirmation; the underlying mechanism possibly relies on the downregulation of miR-4324 and ESR1, and the upregulation of RACGAP1 and p-STAT3 in the miR-4324-RACGAP1-STAT3-ESR1 feedback loop [6].