Aminoglycosides are also used extensively in the treatment of infections with P. aeruginosa; thus, the predominant resistance mechanism to these antibiotics is mediated by the enzymatic modification of the antibiotic via aminoglycoside-acetyltransferases (AACs), aminoglycoside-adenyltransferases (AADs), and aminoglycoside-phosphotransferases (APHs). Here, AACS is linked to infection.