Overall, these studies identified different prescribing predictors related generally to the patient’s presenting symptoms and diagnoses (e.g., positive ear findings, no vomiting, parents beliefs [24], tonsillitis or sinusitis [23]), laboratory test results (e.g., presence of nitrite, leukocytes, or erythrocytes [32] or elevated C-reactive protein (CRP) level [24]), the duration of consultations (e.g., short consultations [23]), and presenting to OOH care, which was associated with higher prescribing odds [25]. The gene discussed is CRP; the disease is tonsillitis.