The pathogenicity of Salmonella infections is determined not only by the invading bacterium, but is also to the host’s susceptibility factors such as age (young children and elderly individuals are more susceptible due to immature or weakened immune systems); genetic (polymorphisms in immune response genes: e.g., NOD2, TLR4, IL-10, hereditary conditions like hemochromatosis, and HLA type variations); and environmental factors (malnutrition, co-infections: e.g., HIV, and poor hygiene and sanitation significantly increase susceptibility to Salmonella infections) [20,21,22,23]. The gene discussed is TLR4; the disease is Salmonella Infections.