While F. nucleatum has long been suggested to induce the proliferation of CRC cells and tumor development [6], the ability of ØTCUFN3 to suppress F. nucleatum-induced colorectal cancer cell growth was investigated using HCT-116 p53 wild-type (p53+/+) and p53 knockout (p53−/−) colorectal cancer cell lines. This evidence concerns the gene TP53 and colorectal cancer.