However, seven genes were down-regulated in large individuals of DF × SS, including hemicentin-1 (HMCN1), lengsin (LGSN), Wiskott–Aldrich syndrome protein family member 3 (WASF3), putative protein FAM47C (FAM47C), toll-like receptor 3 (TLR3), probable G-protein coupled receptor 34 (Gpr34), and inter-alpha-trypsin inhibitor heavy chain H3 (ITIH3). The gene discussed is LGSN; the disease is dengue disease.