In a study by Tanamati et al. [45], Murrah buffaloes suffering subclinical mastitis experience an increase in mRNA expression of the TLR-2 and TLR-4 genes with a concomitant higher mRNA expression of TNF-α, IL-1β, and IL-8 genes in somatic cells (SCs), which have been registered. The gene discussed is CXCL8; the disease is mastitis.