LIN28B and cancer: Lin28a and Lin28b, homologs of the Caenorhabditis elegans heterochronic gene Lin28, encode RNA-binding proteins, which can disturb the maturation process of let-7 microRNAs (miRNAs) or modulate mRNA translation [5], thereby regulating the self-renewal of mammalian embryonic stem cells, organismal growth and metabolism, somatic reprogramming and cancer.