In our opinion, this result could reflect that the loss of pRb would only behave as a predictor of cancer risk in oral leukoplakia, as discussed above, whereas in the other OPMDs, the interpretation is uncertain due to the small sample size and clinical heterogeneity, and it could be insufficient to elucidate whether the lack of significance derives from a lack of relevance of pRb in their malignant transformation or if it is indicative of a lack of statistical power. This evidence concerns the gene RB1 and Oral leukoplakia.