CD30 is one of the factor receptors for tumor necrosis, typically expressed in specific hematological malignancies and primarily manifested on the surface of various malignant cells, e.g., Reed–Sternberg cells in HL, different T-cell cancers, systematic anaplastic large cell lymphoma cells, embryonal carcinomas, and other hematological malignancies [161,163]. This evidence concerns the gene TNFRSF8 and hematologic disorder.