Furthermore, these compounds inhibit metastatic ability by modulating key pathways such as PI3K/AKT, JAK/STAT, and HIF-1α, suppressing matrix-degrading enzymes like MMPs, reducing cell adhesion and migration, and disrupting the tumor microenvironment through antioxidant, anti-inflammatory, and anti-angiogenic mechanisms [27,28,29,30]. This evidence concerns the gene HIF1A and neoplasm.