A study by Gyémánt et al. [132] highlighted the ability of carotenoids, such as capsanthin and zeaxanthin, to reverse MDR by inhibiting P-glycoprotein also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1), an efflux pump that reduces intracellular drug concentrations in resistant cancer cells. This evidence concerns the gene ABCB1 and cancer.