POU5F1 and Familial prostate cancer: We and others have identified other members of the pluripotent stem cell transcriptional circuitry [55] as being important AR-regulated oncogenes in prostate cancer, including SOX2 [25,56,57,58] and NANOG [59,60]; however, we rarely see these co-expressed in cancer, or in particular, expressed with OCT4 [25].