Dysregulation of PI3K/Akt signaling and constitutively active NF-κB have been recently implicated in the upregulation of IL-1β in prostate cancer cells [84] and could be plausibly involved—at least in part—in the production and secretion of this cytokine, as previously reported for these cells [62,63]. The gene discussed is IL1B; the disease is Familial prostate cancer.