TP53 and B-cell chronic lymphocytic leukemia: The LC50 values (concentration required for 50% loss of viability) for each primary CLL sample, as summarized in Figure 2C, indicate that TP53 wild-type CLL cells overall were sensitive to HDM201-induced cytotoxicity (median LC50 = 0.253 μM), whereas CLL samples with mutated TP53 were substantially more resistant (median LC50 = 2.63 μM; Figure 2C).