Significantly higher levels of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and T-cell immunoglobulin and mucin domain 3 (TIM-3) or lymphocyte-activation gene 3 (LAG-3) expression were found on CAR-T cells of non-responders with CLL [160]. This evidence concerns the gene HAVCR2 and B-cell chronic lymphocytic leukemia.